In 2006, Bowden scored her first acting role in a two-episode arc on the ABC long-time running daytime soap opera television series One Life to Live as Britney. She has since guest starred on shows such as Law & Order: SVU and Ugly Betty. Bowden's breakthrough role came when she was cast as a recurring character on the Emmy Award-winning television series 30 Rock, which premiered on October 11, 2006 on NBC. She portrayed the sexy but incompetent assistant Cerie. She signed on as a regular for the show's second season in 2007. The show's final episode aired in January 2013, in total consisting of 7 seasons. She appears in the music videos "Dance, Dance" by American rock band Fall Out Boy, as well as "After Hours" by Brooklyn band We Are Scientists. She also appeared in the music video "Miss Jackson" by Panic! at the Disco.