Ximena got her start on the reality show Protagonistas de Novela, dedicated to seeking acting talents. In 2005, she began her acting career in the telenovela Soñar no cuesta nada, where she played Jenny. In 2007 participates in Pecados Ajenos as María Águilar. The next year is part of the telenovela Valeria playing Ana Lucía Hidalgo. Also part of the telenovela El rostro de Analía, where she shared credits with Elizabeth Gutiérrez. In 2009 she had a small role in the telenovela Victorinos. Throughout the years, Ximena Duque has acted in several telenovelas with Telemundo.