During her career, Elise has appeared in films such as John Q. (2002), The Manchurian Candidate (2004), Diary of a Mad Black Woman (2005), The Great Debaters (2007), For Colored Girls (2010), Dope (2015), Almost Christmas (2016) and Death Wish (2018). She received a nomination for Independent Spirit Award for Best Female Lead for her performance in the 2004 drama film, Woman Thou Art Loosed, and played the leading roles in a number of made for television movies. Elise also starred in the CBS crime drama series, Close to Home (2005–07), and in 2013 began starring in the VH1 comedy-drama series, Hit the Floor. She is four-time NAACP Image Awards winner.